Eif2ak2 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comEif2ak2 CLIA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Eif2ak2(Gene name) > Rat

Eif2ak2 (Gene name),

Interferon-induced, double-stranded RNA-activated protein kinase (Protein name ), E2AK2_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Eif2ak2(Prkr);

Protein name:

Interferon-induced, double-stranded RNA-activated protein kinase;

Alternative:

Interferon-inducible RNA-dependent protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2(eIF-2A protein kinase 2);2.7.10.2;Tyrosine-protein kinase EIF2AK2);Protein kinase RNA-activated(PKR);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with DNAJC3 (By similarity). Interacts with STRBP. Forms a complex with FANCA, FANCC, FANCG and HSP70.

Function:

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

513

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

513:

WKNISEKKKR | NTC

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Rn.10022

KEGG:

rno:54287

SMR:

Q63184

Pfam:

PF00035

Uniprot:

Q63184

FOR

ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

E1135m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

P1135Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase

Protein for Rat Interferon-induced, double-stranded RNA-activated protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase."
Mellor H. , Flowers K.M. , Kimball S.R. , Jefferson L.S.
Biochim. Biophys. Acta1219:693-696(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
2.

"A new double-stranded RNA-binding protein that interacts with PKR."
Coolidge C.J. , Patton J.G.
Nucleic Acids Res.28:1407-1417(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STRBP
3.

"Blocking the eIF2? kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory."
Stern E. , Chinnakkaruppan A. , David O. , Sonenberg N. , Rosenblum K.
J. Neurosci.33:2517-2525(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

Product Feedback Wall

* Email:
*Comments: